Monica ma aysan raadin inay dhisato xirfad shaqo. Waxay rabtay inay noqoto garyaqaan wanaagsan, si ay jaamacadda u gasho, waxay u shaqeyn jirtay sidii ay da'doodu ahayd 16 jir. Laakiin ugu dhakhsaha badan waxay jeceshay nolosha bulshada, waxayna go'aansatay inay sii wado raalligelinta, iyada oo riyadeeda ku noqotay inay noqoto qareen.
Monica waxay ku fiicnayd luqado badan, sida Ingiriis, Faransiis, Dabcan Talyaani iyo wax yar oo Isbaanish ah.
Doorka dhabta ah ee ay heshay 1992-dii, markii loo soo bandhigay kaalinta ay ka ciyaaraan aroosadda arooska Dracula ee filinka "Dracula". Ka dib doorarkan, waxay ka heshay dalabyo cusub oo ka yimid istuudiyaha filimada ee Caanka ah ee Yurub iyo Maraykanka. Guusha Monica waxay timaaddaa doorka filinka "Apartment" 1996 iyo waxay heshay abaalmarinta "Cesar". Waxay ahayd markii filimkan filimkan Monica ay ogaatay ninkeeda mustaqbalka Vincent Cassel. Waxay sidoo kale ku dhalatay filimka Faransiiska ee Doberman.
Laga soo bilaabo 1997-illaa 1998, Monica waxay kuxirantahay 7 muuqaal: "Dhibaato", "Bad Tone", "Sidee Ayaad I dooneysaa", "Doon", "Ma jiri doonto fasax", "Ku saabsan kuwa jecel", "Iskuday". Laakiin tan Bellucci ma joojin, waxay heshay soo jeedin cusub, laakiin ma aysan degdegin inay ka muuqato filim kasta oo la soo bandhigay. Monica ayaa aad u doonaysay doorka la soo jeediyay ee la soo bandhigay. Waxay dooratay oo keliya doorarka ay ku muujin karto tayada waxqabadkeeda.
Isaga oo dunida oo dhan loo yaqaano model iyo actress, Monica waxay ka muuqaneysaa daboolka majaladaha dhalaalaya. Bellucci wuxuu ugu dambeyntii soo bandhigay tayadeeda filimka "Malena", oo qabta qalbiyada dhammaan daawadayaasha iyo kuwa naqdiya. Si aad u joojiso filimada hal dabeecad Monica marna ma rajayn, oo go'aansaday in ay ku ciyaaraan filimka filim culus "Samee Masiixa".
Bellucci ma joojin ilaa hadda iyo waxaa loo toogtay filimyo kala duwan, oo noqda actorka ugu sarreeya Hollywood.
Monica sidoo kale waxay noqotay wejiga shirkadda "Royal Velvet" Oriflame iyo wejiga wajiga cosmiska Dolce & Gabbana.